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Zellweger Syndrome Is Caused by Defects in Genes Coding for Peroxisomal

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Zellweger syndrome is caused by defects in genes coding for peroxisomal protein import. Why are defects in such genes more likely to be lethal than a defect in a gene encoding a single enzyme present in the peroxisomal lumen?

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A defect in import machinery affects the...

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