A Researcher Generated a Mutant SH2-Containing Protein Such That It

A researcher generated a mutant SH2-containing protein such that it binds tyrosine and phosphotyrosine with equal affinity. As a result, MEK activity would be expected to

A) increase with ligand binding-induced dimerization.
B) remain the same with receptor dimerization and autophosphorylation.
C) decrease due to changes in Raf activation.
D) decrease due to allosteric inhibition of SH2-domain binding.

Correct Answer:

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