An Endocrainologist Is Trying to Study the Pathophysiology of Insulin

An endocrainologist is trying to study the pathophysiology of insulin production. If he detects a mutation in the insulin gene. And this results in a single amino acid substitution in the proinsulin molecule. The endocrainologist concluds that the amino acid substitution affects a segment of proinsulin removed during post-translational processing of the protein.  The polypeptide segment containing the mutation is most likely to undergo which of the following processes within pancreatic beta cells?

A) Degradation in lysosomes
B) Degradation in proteasomes
C) Degradation in the rough endoplasmic reticulum
D) Direct translocation across the plasma membrane
E) Storage in secretory granules

Correct Answer:

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