A Newborn by Normal Vaginal Delivery Is Brought for Routine

A newborn by normal vaginal delivery is brought for routine screening. you found an increase in TSH and low thyroxine T4 serum level. Apgar scores were 8 and 9 at 1 and 5 minutes, respectively. His mother has no medical conditions. Physical examination reveals normal thyroid gland in the normal position. Neck ultrasound confirms the normal size of the thyroid. Which of the following is the most likely cause of this patient's findings?

A) Central hypothyroidism
B) Generalized resistance to thyroid hormones
C) Thyroid gland resistance to TSH
D) Thyroid hormone-binding globulin deficiency
E) TSH receptor-stimulating antibodies

Correct Answer:

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