A 45-Year-Old Woman Is Examined Two Weeks After Breaking Her

A 45-year-old woman is examined two weeks after breaking her left radius in a fall from standing height. She had passed a renal stone two months prior. There is no history of osteoporosis or hypercalcemia in the family. The physical exam is unremarkable. The following are the serum laboratory results: 11ec160b 3abb 7e90 9249 2faf1d8276f1 MD0001 00 The use of dual-energy x-ray absorptiometry to measure bone density reveals osteoporosis. Which of the following is the major contributor to bone loss in this patient?

A) Decreased bone formation due to decreased conversion of calcidiol to calcitriol
B) Decreased bone formation due to excessive loss of calcium in urine
C) Decreased bone formation due to inhibition of osteoblast differentiation
D) Increased bone resorption due to decreased intestinal calcium absorption
E) Increased bone resorption due to paracrine stimulation of osteoclasts

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