A New Novel Drug X Has Been Discovered Recently, and It

A new novel drug X has been discovered recently, and it is under experiment. This drug is eliminated primarily by the kidney. A healthy volunteer of body weight 60 kg (132.3 lb) is recruited, and his glomerular filtration rate is 100 mL/min. In this volunteer, plasma concentration of the drug, immediately after intravenous administration, is 0.5 mg/mL. Urinary excretion rate of the drug is found to be 75 mg/min. When another medication, drug Y, is coadministered, urinary excretion rate of the drug X is 50 mg/min. Which of the following effects of drug Y on the pharmacokinetics of drug X best explains the findings in this study?

A) Decreased renal tubular reabsorption
B) Decreased renal tubular secretion
C) Displacement from plasma proteins
D) Increased glomerular filtration

Correct Answer:

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