A 35-Year-Old Guy Visits the Office to Have a Rash

A 35-year-old guy visits the office to have a rash on his elbows evaluated. This rash has been bothering the patient periodically for several months, but it has recently grown more persistent and unpleasant. He's had slight itching but no discomfort, and he's tried a topical moisturizing lotion without success. The patient works at a home construction firm, installing tile flooring. He has no chronic medical concerns and does not use any drugs on a daily basis. The patient does not smoke, drink alcohol, or use illegal drugs. The vital indicators are within normal ranges. The rash on his elbow is seen here, and a similar rash can be seen on his other elbow. Which of the following histologic changes would be most likely if this patient's skin lesion were biopsied?

A) Epidermal hyperplasia
B) Granulomatous inflammation
C) Intense eosinophilic infiltration
D) Squamous cell dysplasia
E) Thinning of the epidermis

Correct Answer:

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