A 65-Year-Old Man Visits the Clinic After Experiencing Itching, Ulceration

A 65-year-old man visits the clinic after experiencing itching, ulceration, and crusting of a skin lesion on his upper chest for two months. The patient was diagnosed with squamous cell carcinoma with perineural invasion at the lesion location a year ago. The tumor was surgically resected with clean margins, and adjuvant radiation was administered to the location. He has no additional symptoms. The exhibit depicts the patient's lesion.   If a biopsy is performed at the periphery of the lesion, which of the following histologic changes is most likely to be seen?

A) Full-thickness epidermal necrosis
B) Homogenization of dermal collagen bundles
C) Neutrophilic infiltrates and elongated dermal papillae
D) Perivascular collections of eosinophils

Correct Answer:

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