A 50-Year-Old Man Arrives at the Clinic for an Evaluation

A 50-year-old man arrives at the clinic for an evaluation before undergoing left total knee arthroplasty. A person's medical history is important when it comes to osteoarthritis. The patient does not use tobacco. A 1.5-cm round lesion in the periphery of the right upper lobe of the lung is visible on a preoperative chest x-ray. Further imaging studies indicate a pulmonary hamartoma. If a transthoracic biopsy were performed, which of the following microscopic features would be most consistent with this diagnosis?

A) Atypical cells lining alveoli without invasion
B) Expression of neuroendocrine markers
C) Invasive nests with keratin pearl formation
D) Nodules of cartilaginous tissue
E) Sheets of large pleomorphic cells

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