A 38-Year-Old Man Is Evaluated for Bloody Stools, Weight Loss

A 38-year-old man is evaluated for bloody stools, weight loss, and anemia. The patient's medical history is unremarkable, and he does not take any medications. He smokes and consumes alcohol "socially." The patient's father died of colon cancer at the age of 40. His younger sister is afflicted with endometrial cancer. Examination reveals minimal right-sided abdominal tenderness without guarding against deep palpation. The stool tests positive for occult blood. A colonoscopy reveals a right-sided ulcerative colon mass. There are no polyps discovered. Adenocarcinoma is discovered after a mass biopsy.A mutation in which of the following genes is most likely responsible for this patient's condition?

A) APC
B) BRCA1
C) MEN1
D) MSH2
E) VHL

Correct Answer:

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