A 57-Year-Old Man Comes to the Physician Because of a 2-Month

A 57-year-old man comes to the physician because of a 2-month history of worsening shortness of breath with walking. He has not had any cough, fevers, or recent weight loss. He has hypercholesterolemia, for which he takes simvastatin, but otherwise is healthy. He smoked 2 packs of cigarettes daily for 35 years. On lung auscultation, there are reduced breath sounds at the base of the left lung. An X-ray shows a left pleural effusion and multiple nodular pleural lesions. Electron microscopy shows tumor cells with long and slender microvilli are joined by desmosomes. Which of the following is the most likely diagnosis?

A) Adenocarcinoma
B) Carcinoid lung tumor
C) Mesothelioma
D) Small cell carcinoma
E) Squamous cell carcinoma

Correct Answer:

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