A 39-Year-Old Woman Presents to the Office Due to a 3-Week

A 39-year-old woman presents to the office due to a 3-week history of increasing fatigue. She says that she feels less energetic than before and cannot complete the morning walks she previously liked to take. Physical exam reveals conjunctival pallor, hepatomegaly, and massive splenomegaly.   Further evaluation reveals a gain-of-function mutation of a non-receptor tyrosine kinase protein in hematopoietic cells, leading to persistent activation of signal transducers and activators of transcription (STAT) proteins.  This patient is most likely suffering from which of the following disorders?

A) Acute promyelocytic leukemia
B) Chronic lymphocytic leukemia
C) High-grade non-Hodgkin lymphoma
D) Mantle cell lymphoma
E) Primary myelofibrosis

Correct Answer:

Verified

Unlock this answer now
Get Access to more Verified Answers free of charge

Access For Free