A 2-Week-Old Infant Is Brought to the Emergency Department Due

A 2-week-old infant is brought to the emergency department due to fever, lethargy, grunting, and poor feeding.  The patient was born at full term after an uneventful pregnancy and has had no prior medical issues.  Blood samples are obtained for culture, and the patient is hospitalized for broad-spectrum antibiotic therapy.  Cultures grow Escherichia coli.  The patient's condition developed in part due to exposure to bacterial lipopolysaccharide, which stimulates NF-kB-induced transcription of inflammatory cytokines such as TNF-alpha, IL-1, and IL-6.  This bacterial component most likely interacted with the patient's immune cells via which of the following?

A) Beta-2 integrin
B) Fc receptor
C) L selectin
D) MHC class II molecule
E) Mannose-binding lectin
F) Toll-like receptor

Correct Answer:

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