A 2-Year-Old Boy Is Brought to the Emergency Department Due

A 2-year-old boy is brought to the emergency department due to 4 days of worsening cough and fevers.  This evening, the patient developed increasingly rapid breathing.  He has a history of 2 prior episodes of cervical lymphadenitis due to Staphylococcus aureus.  Temperature is 39 C (102.2 F) .  Blood pressure is 100/72 mm Hg, pulse is 130/min, and respirations are 35/min.  Prominent intercostal and supraclavicular retractions are present.  There are diffuse crackles bilaterally, with decreased breath sounds at the lung bases.  Heart sounds are normal.  The patient is intubated.  Laboratory results are as follows: Bronchioalveolar lavage fluid tests positive for Aspergillus fumigatus.  Serum immunoglobulin levels are normal.  Which of the following is the most likely underlying cause of this patient's presentation?

A) Decreased macrophage degranulation
B) Disrupted macrophage phagocytosis
C) Dysfunctional neutrophil trafficking
D) Impaired neutrophilic respiratory burst
E) Reduced neutrophilic phagocytosis

Correct Answer:

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