An 8-Year-Old Boy Is Evaluated in the Office for Walking

An 8-year-old boy is evaluated in the office for walking difficulties. Running, jumping, and walking up stairs are all difficult for the patient. There is no family history of neurological disorders. A physical examination reveals bilateral weakness of lower extremity muscles. The image below shows electron microscopy of a calf muscle biopsy sample. Which of the following labeled regions contains only thick filaments and no thin filaments?

A) A
B) B
C) C
D) D
E) E

Correct Answer:

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