A 41-Year-Old Man with Trisomy 21 Is Evaluated in the Clinic

A 41-year-old man with trisomy 21 is evaluated in the clinic due to cognitive decline.  The patient has a history of moderate intellectual disability, but his higher cognitive functions have become progressively impaired in the past several years.  He previously volunteered at a community library but recently lost his position as he could no longer perform his duties.  The patient is now completely dependent on a caregiver for assistance with his activities of daily living such as getting dressed, bathing, and using the toilet.  The patient keeps wandering in the group home and has become lost on several occasions.  Which of the following is most likely to be increased in this patient?

A) Amyloid A protein
B) Amyloid precursor protein
C) Apolipoprotein E epsilon 4
D) CAG trinucleotide repeats
E) Islet amyloid polypeptide

Correct Answer:

Verified

Unlock this answer now
Get Access to more Verified Answers free of charge

Access For Free