A 40-Year-Old Woman Is Enrolled in a Research Study

A 40-year-old woman is enrolled in a research study.  She has a 10-year history of Parkinson's disease with resting tremor, bradykinesia, and cogwheel rigidity .  One of her siblings recently started having similar symptoms.  Genetic analysis is performed on the patient and her affected sibling.  The results show a loss-of-function mutation in a gene that leads to an accumulation of misfolded proteins.  Which of the following biochemical processes is most likely defective in this patient?

A) Acetylation
B) Gamma-carboxylation
C) Glucuronidation
D) Phosphorylation
E) Ubiquitination

Correct Answer:

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