Erythroblasts Isolated from a Bone Marrow Biopsy Sample of a Patient

Erythroblasts isolated from a bone marrow biopsy sample of a patient with neonatal jaundice are incubated in a medium containing radiolabeled glucose.  The cells are unable to generate NADPH from glucose metabolism but are able to convert fructose-6-phosphate to ribose-5-phosphate, which is required for nucleic acid synthesis.  Which of the following enzymes is essential for the latter conversion?

A) Aconitase
B) Enolase
C) Glucose-6-phosphate dehydrogenase
D) Glutathione reductase
E) Transketolase

Correct Answer:

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