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A Research Scientist Studying the Metabolic Pathways That Contribute to Obesity

Question 68

Multiple Choice

A research scientist studying the metabolic pathways that contribute to obesity feeds experimental animals a high-carbohydrate, high-protein diet for a prolonged period.  A sample of liver tissue is then obtained from the animals, and the activity of various enzymes involved in fatty acid metabolism is measured and recorded.  It is determined that beta-oxidation of fatty acids is inhibited within these cells as a result of the diet.  An increase in which of the following substances is most likely responsible for the observed effect?


A) Acetoacetate
B) Carnitine
C) Citrate
D) Malonyl-CoA
E) NADPH

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