A 72-Year-Old Previously Healthy Man Is Brought to the Office

A 72-year-old previously healthy man is brought to the office by his wife because of strange movements and behavior during sleep that have been more frequent in the last three months. She states, "He's been waking me up in the middle of the night lately, wailing and flailing around as if he's having a nightmare. He sometimes turns angry in his sleep, kicking and punching me. I can easily wake him up, although he is frequently perplexed for a few seconds. Then he frequently recounts a dream in which he was protecting himself against an assault." The physical exam is ordinary. The most likely cause of this patient's disease is neurodegeneration caused by the buildup of which of the following?

A) Alpha-synuclein
B) Amyloid beta peptide
C) Prion proteins
D) Tau proteins
E) TAR DNA-binding protein-43

Correct Answer:

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