After Being Pushed into Early Retirement Owing to Poor Job

After being pushed into early retirement owing to poor job performance, a 55-year-old formerly healthy man is taken to the workplace by his wife. The patient used to be a financial planner, but he started missing critical deadlines and mismanaging his clients' money 6 months ago. During this period, he got increasingly angry and began to curse and disrespect his employees when they voiced worry about his performance. The patient has also become verbally aggressive toward his wife, although he appears oblivious to the pain he is causing. She has had to take charge of the money as well as the grocery shopping. She continues, "My spouse has developed a significant sweet tooth. He now consumes nearly two cartons of cookies every day." The physical exam is ordinary. This patient is most likely to have which of the following neuropathologic findings?

A) Aggregations of phosphorylated tau protein
B) Cytoplasm inclusions with alpha synuclein
C) Cytosolic vacuolation of neurons and glia with prion inclusions
D) Extracellular deposition of beta-amyloid
E) Intracellular deposition of presenilin

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