The Drug Advertisement Suggests That BoXeva Should Be Added to Metformin

The drug advertisement suggests that BoXeva should be added to metformin for the treatment of patients with type 2 diabetes mellitus. A 56-year-old woman comes to the office for follow-up.  She has a history of type 2 diabetes mellitus and hypertension.  The patient has been on metformin therapy for the past 6 months.  Despite adhering to a diabetic diet and increasing her level of physical activity, she has been unable to lose weight.  At the current visit, her blood pressure is 145/90 mm Hg, and heart rate is 72/min.  Her weight is 82 kg (180 lb) .  HbA_1c is 7.6%, and serum creatinine is 0.9 mg/dL.
Compared to adding BoXeva, adding glimepiride to this patient's current regimen will most likely lead to which of the following at 52 weeks of treatment?

A) Higher chance of sustained glycemic control
B) Higher insulin resistance
C) Higher risk of stroke
D) Lower compliance rate
E) Similar effect on glycemic control

Correct Answer:

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