Two Independent Research Groups Are Studying the Effect of a New

Two independent research groups are studying the effect of a new anticoagulant on the incidence of deep-vein thrombosis after hip replacement surgery.  The first group designs a 1:1 randomized trial with 1000 patients comparing the new drug with the standard of care (500 patients in each group) .  The second group designs a similar randomized trial but intends to recruit 500 patients (250 patients in each group) .  Assuming similar populations for patient recruitment, the small study has a higher chance of which of the following?

A) Early termination
B) Outcome misclassification
C) Selection bias
D) Type I error
E) Type II error

Correct Answer:

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