A 29-Year-Old Man Comes to the Physician for a Routine

A 29-year-old man comes to the physician for a routine preventive examination.  He is currently feeling well but states that he has always had "some dark spots" on his back.  The patient has no family history of heart disease or cancer.  He does not spend much time outdoors and had no prior sunburn.  He does not smoke.  Physical examination shows many pigmented lesions on his back as shown below.
Which of the following is the best factor to assess risk of malignancy in a suspicious skin lesion in this patient?

A) Café-au-lait lesion
B) Herald patch
C) Similarity to other skin lesions
D) "Stuck-on" appearance
E) Variability in color

Correct Answer:

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