A 62-Year-Old Man with Hypertension and Stage 3 Chronic Kidney

A 62-year-old man with hypertension and stage 3 chronic kidney disease comes to the office due to poor sleep.  The patient describes a crawling sensation in his legs about 15-20 minutes after getting into bed at night.  Walking and pacing or wiggling his legs alleviates the symptoms, but they return when he gets back in bed.  Physical examination shows no lower extremity sensory or motor abnormalities.  The first-line pharmacotherapy for this patient's condition targets a receptor for which of the following substances?

A) Acetylcholine
B) Dopamine
C) Gamma-aminobutyric acid
D) Norepinephrine
E) Serotonin

Correct Answer:

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