A 62-Year-Old Woman Comes to the Office Due to Difficulty

A 62-year-old woman comes to the office due to difficulty remembering important dates and appointments.  She also describes poor concentration, daytime sleepiness, and easy fatigability.  She is concerned about her forgetfulness because her mother suffered from recurrent strokes and had severe memory loss.  Her father died of chronic leukemia.  Her daughter's recent job loss has caused her a lot of stress.  She does not use alcohol or tobacco.  Her appetite is decreased but she has gained 2 kg (4.4 lbs) over the last 3 months.  She recently visited an otolaryngologist for hoarseness.  She takes occasional aspirin for joint pain and has been taking over-the-counter laxatives for constipation.  She denies any other medication use.  Which of the following is the most likely diagnosis in this patient?

A) Alzheimer disease
B) Dementia with Lewy bodies
C) Multiinfarct dementia
D) Hypothyroidism
E) Normal pressure hydrocephalus
F) Huntington disease
G) Chronic subdural hematoma
H) Pseudodementia
I) Vitamin B12 deficiency
J) Thiamine deficiency
K) Drug-induced dementia

Correct Answer:

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