A 23-Year-Old Man Comes to the Physician Saying That His

A 23-year-old man comes to the physician saying that his eyes often have a yellowish hue.  He considers himself healthy, eats well, and exercises regularly.  He does not use tobacco, alcohol, or illicit drugs.  The patient was adopted at a young age and does not know his biological family history.
Vital signs are within normal limits.  The tip of the spleen is palpable on inspiration.  The remainder of the physical examination is unremarkable.
Laboratory values are as follows:

Blood smear shows 3-5 spherocytes per high-power field.
Which of the following is the best next step in the evaluation of this patient?

A) Bone marrow biopsy
B) Direct antiglobulin test
C) Hemoglobin electrophoresis
D) Serum cobalamin levels
E) Serum protein electrophoresis

Correct Answer:

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