A Large Multicenter Double-Blinded Randomized Placebo-Controlled Study Is Being Planned

A large multicenter double-blinded randomized placebo-controlled study is being planned to evaluate a new medication.  Primary endpoints addressing mortality benefits are chosen, and a comprehensive analysis strategy is specified, including for predefined subgroups.
In discussing the advantages of this study design, which of the following represents a benefit of randomization?

A) Randomization can be performed at the level of subgroup analysis
B) Randomization distributes known and unknown variables equally among the study groups
C) Randomization ensures that the study results are statistically significant
D) Randomization ensures that the study sample is representative of the population
E) Randomization prevents group allocation concealment from study participants and investigators

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