An 8-Year-Old Boy Is Evaluated in the Office Due to Difficulty

An 8-year-old boy is evaluated in the office due to difficulty walking.  The patient has problems running, jumping, and walking up steps.  There is no history of neurological disorders in the family.  Physical examination reveals weakness of lower extremity muscles bilaterally.  Electron microscopy of a biopsy sample taken from calf muscle is shown below. Which of the following labeled regions contains only thick filaments and no thin filaments?

A) A
B) B
C) C
D) D
E) E

Correct Answer:

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