An Experimental Substance Is Infused Intravenously at a Constant Rate

An experimental substance is infused intravenously at a constant rate into a healthy volunteer.  The substance is known to selectively constrict the efferent arteriole in renal glomeruli.  The rate of infusion is closely controlled during the experiment to allow for only mild constriction of the efferent arteriole.  Which of the following changes in glomerular filtration rate (GFR) and filtration fraction (FF) is most likely to occur during the infusion of this substance?

A) GFR↓, FF↑
B) GFR↓, FF unchanged
C) GFR↑, FF↓
D) GFR↑, FF↑
E) GFR unchanged, FF↑

Correct Answer:

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