A 36-Year-Old Man Is Evaluated Due to Swelling and Severe

A 36-year-old man is evaluated due to swelling and severe pain of the right foot.  Medical history is significant for kidney transplant due to focal segmental glomerulosclerosis.  The patient is diagnosed with gout and treated with prednisone.  Six weeks later, the patient is seen at follow-up.  He has no foot pain and the swelling has subsided.  Serum uric acid level is 13.5 mg/dL and creatinine level is 0.9 mg/dL.  Allopurinol is prescribed.  Initiation of this drug would most likely increase the activity of which of the following medications?

A) Azathioprine
B) Ganciclovir
C) Prednisone
D) Tacrolimus
E) Trimethoprim

Correct Answer:

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