A 56-Year-Old Man with a History of Severe Depression Seeks

A 56-year-old man with a history of severe depression seeks a new physician after immigrating to the United States.  His depression has been treated with phenelzine since diagnosis, and his new physician decides to switch him to sertraline.  The patient is informed that he must wait at least 2 weeks after discontinuing phenelzine before starting the new drug.  Which of the following processes occurs during this washout interval to allow sertraline therapy to be initiated safely?

A) G protein-coupled receptor internalization
B) Inositol monophosphatase inhibition
C) Monoamine oxidase inhibition
D) Monoamine receptor downregulation
E) Monoamine reuptake inhibition
F) Synthesis of monoamine oxidase

Correct Answer:

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