A 57-Year-Old Caucasian Male with Severe Pyelonephritis Is Admitted to the Hospital

A 57-year-old Caucasian male with severe pyelonephritis is admitted to the hospital.  His past medical history is significant for diabetes, hypertension, and two episodes of transient ischemic attacks.  His serum creatinine level is 3.2 mg/dL; therefore, he needs to be started on an antibiotic that depends mainly on non-renal clearance.  Which of the following characteristics should the antibiotic also have if hepatic metabolism and clearance is desired?

A) Low volume of distribution
B) Poor oral absorption
C) High lipophilicity
D) Low rate of redistribution
E) Poor penetration into the CNS

Correct Answer:

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