Researchers Are Conducting a Study to Determine the Effectiveness of a Novel

Researchers are conducting a study to determine the effectiveness of a novel humanized monoclonal antibody in patients with metastatic colorectal cancer.  This medication works by binding to the programmed cell death-1 receptor on T cells to block its ligands from binding.  They find this therapy is most effective in patients with a high degree of microsatellite instability or defects in DNA mismatch repairs.  Which of the following best explains the favorable drug effect in this subset of patients?

A) Higher expression of P-glycoprotein
B) Higher number of cancer neoantigens
C) Higher rate of KRAS mutations
D) Higher rate of p53 mutations
E) More intense desmoplastic reaction

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