A 62-Year-Old Man Is Hospitalized with Severe Abdominal Pain and Diarrhea

A 62-year-old man is hospitalized with severe abdominal pain and diarrhea after a recent urinary tract infection.  Six months ago, the patient had an episode of Clostridium difficile colitis after being treated for pneumonia.  Medical history is also significant for diverticulitis and upper gastrointestinal tract bleeding.  The patient is allergic to penicillin.  An appropriate workup confirms C difficile colitis.  The patient is placed on an oral macrocyclic antibiotic that inhibits the sigma subunit of RNA polymerase.  Which of the following agents was most likely administered to this patient?

A) Doxycycline
B) Fidaxomicin
C) Metronidazole
D) Neomycin
E) Vancomycin

Correct Answer:

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