A Study Is Conducted to Assess the Effect of Parathyroid

A study is conducted to assess the effect of parathyroid hormone (PTH) on bone remodeling.  Half of the study subjects receive intermittent PTH injections and the other half receive a continuous infusion of PTH.  The results show that the effects on bone metabolism of intermittent PTH injections are different from those of continuous infusion.  Which of the following is most likely to be the predominant bone effect with intermittent injections?

A) Increased activity of matrix metalloproteinases
B) Increased levels of osteoprotegerin
C) Osteoclast apoptosis
D) Stimulation of osteoblast activity
E) Suppression of RANK and RANK-ligand activity

Correct Answer:

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