A 34-Year-Old Man Diagnosed with Advanced Non-Hodgkin Lymphoma Undergoes Doxorubicin-Containing

A 34-year-old man diagnosed with advanced non-Hodgkin lymphoma undergoes doxorubicin-containing chemotherapy with good clinical response.  Several weeks after the last chemotherapy cycle, the patient comes to the office with progressive exertional dyspnea.  He has difficulty sleeping flat at night and needs to use multiple pillows to fall asleep.  The patient is a lifetime nonsmoker and has no family history of heart disease.  Blood pressure is 124/72 mm Hg, pulse is 86/min, and respirations are 16/min.  Oxygen saturation on room air is 96%.  Which of the following is most likely responsible for this patient's current symptoms?

A) Dilated cardiomyopathy
B) Focal myocardial scarring
C) Hypertrophic cardiomyopathy
D) Pericardial thickening and fibrosis
E) Restrictive cardiomyopathy
F) Right ventricular pressure overload

Correct Answer:

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