A 28-Year-Old Man Is Found Unresponsive by His Roommate

A 28-year-old man is found unresponsive by his roommate.  The roommate states the patient returned late last night after a party, and this morning he was unable to wake the patient up.  Paramedics find the patient without respirations and pulse and declare him dead.  Autopsy examination shows hemorrhage in the basal ganglia and midbrain that extends into the third ventricle.  There is no arteriosclerosis or fibrinoid necrosis of the arterioles.  Scattered areas of infarcted subendocardial myocardium are also seen.  A substance with which of the following synaptic effects most likely predisposed this patient to death?

A) Blockade of postsynaptic neurotransmitter receptors
B) Decreased metabolism of released neurotransmitters
C) Impaired presynaptic neurotransmitter reuptake
D) Increased formation of neurotransmitter vesicles
E) Increased presynaptic neurotransmitter synthesis

Correct Answer:

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