A 72-Year-Old Man Is Hospitalized Due to Fatigue, Orthopnea, and Exertional

A 72-year-old man is hospitalized due to fatigue, orthopnea, and exertional dyspnea.  The patient takes no medications and has not seen a physician in many years.  He is a lifelong nonsmoker.  His blood pressure is 110/60 mm Hg and pulse is 64/min.  Examination reveals bibasilar crackles, elevated jugular venous pressure, and bilateral lower extremity pitting edema.  His left ventricular end-diastolic pressure-volume is shown in the graph below (purple curve) . Which of the following is the most likely cause of this patient's condition?

A) Alcohol-induced cardiomyopathy
B) High-dose doxorubicin therapy
C) Selenium deficiency
D) Transthyretin deposition
E) Viral myocarditis

Correct Answer:

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