A 75-Year-Old Man Is Brought to the Emergency Department by Paramedics

A 75-year-old man is brought to the emergency department by paramedics following a high-speed motor vehicle accident.  Several attempts are made to resuscitate him but are unsuccessful.  The patient had no significant past medical history and took no medications.  He was known to be in good health and tolerant of moderate levels of physical activity.  Electrocardiogram findings at his last office visit showed no abnormalities.  At autopsy, heavy calcifications of the aortic valve are seen.  Which of the following most likely preceded the aortic valve changes observed in this patient?

A) Cell necrosis
B) Extracellular amyloid deposition
C) Hypercalcemia
D) Intracellular hemosiderin accumulation
E) Pathologic cell hypertrophy

Correct Answer:

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