A 56-Year-Old Construction Worker Comes to the Office After Receiving

A 56-year-old construction worker comes to the office after receiving a letter from his employer advising him of significant exposure to asbestos during a building project 25 years ago.  He is currently asymptomatic and feels well.  Medical conditions include hypertension and osteoarthritis, for which he takes amlodipine daily and ibuprofen as needed.  The patient quit smoking 10 years ago and does not use alcohol or illicit drugs.  Physical examination is within normal limits.  Chest imaging is normal.  He is concerned about his risk of developing cancer.  Due to his occupational exposure, this patient is at greatest risk of malignancy arising from which of the following?

A) Bronchial epithelium
B) Hematopoietic stem cells
C) Liver parenchyma
D) Nasopharyngeal epithelium
E) Pancreatic ductal cells
F) Pleura mesothelium
G) Urinary bladder epithelium

Correct Answer:

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