A 26-Year-Old Man Comes to the Office Due to Myalgia

A 26-year-old man comes to the office due to myalgia, nasal congestion, and cough.  Temperature is 38.3 C (100.9 F) .  Examination shows nasal and pharyngeal hyperemia.  Rapid influenza antigen testing of nasopharyngeal secretions is positive.  Within the infected cells of the patient's respiratory tract, viral proteins are degraded and attached to major histocompatibility complex class I molecules, which are then expressed on the cell surface for presentation to cytotoxic CD8⁺ lymphocytes.  Which of the following enzymes is most essential to initiating this process?

A) Acid phosphatase
B) Caspase
C) Guanylate cyclase
D) Myeloperoxidase
E) Ubiquitin ligase

Correct Answer:

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