A 32-Year-Old Woman Comes to the Office for Evaluation of a Breast

A 32-year-old woman comes to the office for evaluation of a breast lump.  She noticed the lump a few months ago but thinks it might be getting larger.  The patient has a history of right lower limb amputation at age 17 due to osteosarcoma.  The patient's mother died of an adrenal tumor, and her younger sister died of leukemia.  Examination of the left breast shows a 5-cm, firm immobile mass with irregular borders.  Which of the following gene mutations is the most likely etiology for this patient's condition?

A) APC
B) BRCA1
C) NF2
D) TP53
E) RB1

Correct Answer:

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