A 50-Year-Old Man Is Scheduled to Undergo a Colonoscopy for Routine

A 50-year-old man is scheduled to undergo a colonoscopy for routine colorectal cancer screening.  He has no abdominal pain, gross blood in the stool, constipation, change in stool caliber, or unintentional weight loss.  He also has no family history of colon cancer.  The procedure is uncomplicated, but the patient is found to have a small mucosal lesion (~1 cm) in his sigmoid colon.  The lesion is biopsied and its histology is shown in the image below. The pathogenesis of this patient's lesion most likely began with a mutation involving which of the following genes?

A) APC
B) DCC
C) K-RAS
D) MSH2
E) p53

Correct Answer:

Verified

Unlock this answer now
Get Access to more Verified Answers free of charge

Access For Free