A 62-Year-Old Woman Comes to the Physician After Finding a Lump

A 62-year-old woman comes to the physician after finding a lump in her breast.  Physical examination reveals a firm, immovable, irregularly shaped mass.  Mammography is performed and shows a spiculated, calcified lesion that was not seen on prior studies.  A tissue biopsy is diagnostic for infiltrating ductal carcinoma.  Malignant tumors such as infiltrating ductal carcinoma are typically associated with varying degrees of disordered differentiation and maturation.  Which of the following findings is most characteristic of an anaplastic tumor?

A) Brain tumor cells forming giant cells
B) Bronchial epithelial cells producing keratin pearls
C) Colonic tumor cells creating glands
D) Hepatic tumor cells synthesizing bile
E) Skin tumor cells producing keratin pearls

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