A Researcher Is Studying Neuronal Changes in Various Physiologic and Pathologic

A researcher is studying neuronal changes in various physiologic and pathologic states.  Microscopic examination of neural tissue obtained from experimental animals reveals neurons with shrunken nuclei and eosinophilic cytoplasm lacking Nissl bodies.  Which of the following is the most likely cause of these findings?

A) Accumulation of abnormal proteins
B) Age-related physiologic changes
C) Defective lysosomal autophagy
D) Irreversible ischemic injury
E) Transection injury of the nerve fiber
F) Transient neural compression

Correct Answer:

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