A Caucasian Male Who Suffers from a Severe Neurological Disease

A Caucasian male who suffers from a severe neurological disease dies of an overwhelming respiratory infection.  Autopsy shows an atrophic precentral gyrus and thin anterior roots of the spinal cord.  Light microscopy reveals a severe loss of neurons in the anterior horn of the spinal cord and in the hypoglossal and ambiguous cranial nerve nuclei; corticospinal tracts stain only faintly, indicating demyelinization.  The patient most likely suffered from which of the following?

A) Amyotrophic lateral sclerosis
B) Poliomyelitis
C) Rabies
D) Huntington disease
E) Friedreich ataxia
F) Vitamin B₁₂ deficiency

Correct Answer:

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