A 35-Year-Old Man Is Being Evaluated for Nontender Cervical Lymphadenopathy

A 35-year-old man is being evaluated for nontender cervical lymphadenopathy that he first noticed while shaving.  A biopsy is performed, and a low-magnification image of the lymph node histology is shown below. Cytogenetic analysis would most likely demonstrate which of the following patterns?

A) BCL-2 overexpression
B) BCR-ABL rearrangement
C) C-MYC overexpression
D) Constitutive tyrosine kinase activation
E) N-MYC overexpression

Correct Answer:

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