A 7-Year-Old Boy Comes to the Office for Follow-Up

A 7-year-old boy comes to the office for follow-up.  A week ago, the patient began having episodes of bloody diarrhea that have since resolved.  His current laboratory studies show elevated blood urea nitrogen and serum creatinine levels.  Complete blood count reveals anemia and thrombocytopenia.  Coagulation studies are within normal limits.  His peripheral blood smear is shown in the image below. Which of the following is the most likely cause of this patient's anemia?

A) Autoimmune hemolytic anemia
B) Erythropoietin deficiency
C) Hemolytic anemia due to oxidative stress
D) Bone marrow fibrosis
E) Microangiopathic hemolytic anemia

Correct Answer:

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