A 9-Year-Old Boy with Beta Thalassemia Major Comes to the Office

A 9-year-old boy with beta thalassemia major comes to the office for a routine red blood cell transfusion.  He was diagnosed at age 6 months and has since received numerous blood transfusions and chelation therapies.  The patient has tolerated each transfusion and chelation therapy well with no immediate reactions or side effects.  Vital signs are normal.  On physical examination, the boy has mild frontal bossing, hepatosplenomegaly, and jaundice.  A recent liver biopsy showed Kupffer cells containing coarse, yellowish-brown cytoplasmic granules.  The granules are most likely composed of which of the following?

A) Amyloid
B) Bilirubin
C) Copper
D) Glycogen
E) Glycolipid
F) Hemosiderin
G) Lipofuscin

Correct Answer:

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